It is 1944. Pregnant, alone, and riddled with guilt, twenty-three-year-old Tess DeMello abruptly gives up her budding career as a nurse and ends her engagement to the love of her life, unable to live a lie. Instead, she turns to the baby's father for help and agrees to marry him, moving to the small, rural town of Hickory, North Carolina. Tess's new husband, Henry Kraft, is a secretive man who often stays out all night, hides money from his new wife, and shows her no affection. Tess quickly realizes she's trapped in a strange and loveless marriage with no way out. The people of Hickory admire and respect Henry but see Tess as an outsider, treating her with suspicion and disdain. When one of the town's golden girls dies in a terrible accident, everyone holds Tess responsible. Henry keeps his secrets even closer now, though it seems that everyone knows something about him that Tess does not. When a sudden Polio epidemic strikes Hickory, the townspeople band together to build a hospital. Tess knows she is needed and defies Henry's wishes to begin working there. Through this work, she begins to find purpose and meaning. Yet at home, Henry's actions grow more alarming by the day. As Tess works to save the lives of her patients, can she untangle the truth behind her husband's mysterious behavior and find the love - and the life - she was meant to have?